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Diabetes Insipidus vs. Diabetes Mellitus: What Are the Differences?

0 2 years ago

Diabetes insipidus and diabetes mellitus are unrelated diseases with similar names. This connection dates back in history before researchers understood that although the conditions have similar symptoms, the causes are markedly different.

Diabetes insipidus (DI) is a rare condition in which the kidneys are unable to retain water, whereas diabetes mellitus is a condition characterized by the inability of the body to produce enough or respond normally to insulin, causing blood sugar (glucose) levels to be abnormally high.

This article will walk through the differences in each of these conditions, what the causes are, and how each is diagnosed and treated.

Causes of Diabetes Insipidus vs. Diabetes Mellitus

Causes of Diabetes Insipidus

Vasopressin (VP), also known as antidiuretic hormone (ADH), is a hormone produced by the hypothalamus and stored in the pituitary gland that helps regulate the osmolarity (concentration) of fluids in the body.

ADH mainly regulates water levels by controlling urine production. When fluid levels are low in the body, ADH is released to conserve water. ADH increases the reabsorption of water in the kidneys. This decreases the volume of urine produced.1


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