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Is it Mental Illness or Mold Toxicity?

0 2 years ago

By Mark Filidei, D.O.

One of my chief tasks as the Director of Integrative/Functional Medicine at Amen Clinics is to work up what we call a “toxic brain” as seen on brain SPECT imaging. Amen Clinics currently has the world’s largest database of brain SPECT scans—over 160,000 scans from patients in over 150 countries—and it affords us a unique view into the functions of the brain. When working up a toxic, or “encephalopathic,” SPECT scan finding, many etiologies need to be considered, including toxins, infections, allergies, medications, and head trauma. Near the top of my list of possible culprits of abnormal SPECT scans are infections and toxins, especially Lyme disease and toxic mold exposure.

Mold Could Thrive in Your Home

It is estimated that half of the buildings in the United States may be “WDB”, meaning water-damaged buildings. Construction techniques in the U.S. turn out to be a feast and buffet for mold and fungal organisms. Our homes here are often built of wood and drywall rather than stone or brick as in Europe. Mold and fungi thrive on drywall, wood, and other soft materials.

Mold thrives in dark and moist environments and doesn’t take much water to get the process going. A small drip from a leaky toilet, shower, or sink is all it takes. Small roof leaks are also common causes. If you see a stain on the ceiling or the wall there is very likely an associated hidden mold growth. This is not the type of mold that you see on the shower wall, but rather it is lurking behind the walls and in air ducts, crawl spaces, attics, and other areas.

Mold Exposure Symptoms

The toxin-producing “black mold” Stachybotrys, as well as other neurotoxic molds, including Aspergillus, Chaetonium, and Wallemia, can have a dramatic effect on the brain and behavior. There are 2 main effects of mold exposure: the physical airway irritating effects like allergies, cough, and fatigue, and the more concerning effects on the central nervous system (CNS) and the brain.

Mental and cognitive health symptoms can include:

Unfortunately, if you’re experiencing these symptoms and go to your primary care physician or a mental health professional, there is about a 99.9% chance that mold will not be considered as a possible cause. It is simply not on the radar screen of the vast majority of physicians. When was the last time your doctor asked you if your home had a water leak? Point made.

Issues in the home are not the only problem; many workplaces are also contaminated with mold, especially older buildings. Schools have been condemned because of mold contamination, office buildings, hotels, and industrial complexes can all be a source of the problem. Many of the government buildings in Washington, DC have been found to have significant mold contamination issues. Our lawmakers in Washington seem to have enough trouble getting things done; the last thing we need is for them to have poorly functioning brains due to toxic mold exposure! Almost everybody could benefit from a brain detox.

Retrace Your Past Experiences

A case in point is a young male patient who came to Amen Clinics with complaints of sleep disturbance, anxiety, and brain fog. He was initially seen by one of our psychiatrists and referred to me for further workup. A careful history-taking found that these symptoms all started when he moved back home from college into his parent’s basement apartment. The whole family seems to have forgotten that the basement flooded on several occasions. Mold diagnostic testing revealed the patient had high levels of mold toxins in his body.

The first step is always to remove oneself from the moldy environment, and then treatment can begin. Treatment for a “Toxic Brain” typically consists of binding agents and other medications, such as antifungals, and metabolic support supplements. This patient improved with proper treatment and remediation of the mold problem. Here was a patient who didn’t need any psychiatric medications; he simply needed the correct diagnosis and appropriate treatment. What would have been the outcome for this patient without the proper diagnosis? He almost certainly would have been misdiagnosed as having a mental illness and treated (unsuccessfully) with psychiatric medications.

The good news is that there are ways to determine if a patient has been exposed to toxic mold and that there are successful treatments available.

Dr. Richie Shoemaker is a pioneer in detecting and treating what he has termed Chronic Inflammatory Response Syndrome or CIRS. It is really a brilliant bit of work. He has found what I would term the “Rosetta Stone” of inflammatory conditions, brought on by not only mold exposure but also Lyme disease and other inflammatory processes. Dr. Dale Bredesen, an Alzheimer’s disease researcher at UCLA and the Buck Center for Aging has found that a significant number of purported dementia cases are actually caused by mold exposure, and not Alzheimer’s disease at all. He published a paper in a 2016 issue the journal Aging linking exposure to specific toxins and CIRS to Alzheimer’s disease. This is an incredibly important finding! Many patients with memory loss and dementia are actually simply toxic from mold, which is a reversible condition. The tragedy is missing the diagnosis and continuing to proceed with treating the patient for something they do not have and missing an effective treatment.

How to Test for Mold

The workup for CIRS includes tests that are widely available via LabCorp and Quest, although they are somewhat esoteric tests, including MMP–9, TGF beta 1, MSH, VEGF, and others. Urine testing for actual mold toxins circulating in the body can also be utilized, however, these results are questioned by some in the field of CIRS treatment.

Brain toxicity due to mold or other toxins and the psychiatric and cognitive health issues associated with it can’t wait. During these uncertain times, your mental well-being is more important than ever and waiting until life gets back to “normal” is likely to make your symptoms worsen over time.


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