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Study sheds light on why long Covid affects so many organs in the body

0 2 years ago

In what they describe as the most comprehensive analysis to date of the virus’s distribution and persistence in the body and brain, scientists at the US National Institutes of Health said they found the pathogen is capable of replicating in human cells well beyond the respiratory tract.

The results, released online on Saturday in a manuscript under review for publication in the journal Nature, point to delayed viral clearance as a potential contributor to the persistent symptoms wracking so-called long Covid sufferers.

Understanding the mechanisms by which the virus persists, along with the body’s response to any viral reservoir, promises to help improve care for those afflicted, the authors said.


“For a long time now, we have been scratching our heads and asking why long Covid seems to affect so many organ systems. This paper sheds some light, and may help explain why long Covid can occur even in people who had mild or asymptomatic acute disease.”


The findings haven’t yet been reviewed by independent scientists, and are mostly based on data gathered from fatal Covid-19 cases, not patients with long Covid or “post-acute sequelae of Sars-CoV-2,” as it’s also called.

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