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“Chronic Lyme” is a wrecked immune system

0 3 years ago

Scientifically, “chronic Lyme” is a condition of immunosuppression, increased susceptibility to infections of all kinds, and the hallmark of immunosuppression: reactivation of latent viruses. The viruses, primarily of the herpes family, are known to cause profound fatigue. The recent work of Kunal Garg and colleagues illustrates the serious nature of “chronic Lyme” as it resembles polymicrobial sepsis:

Incompetent B cells

Spirochetes disseminate to the nearest lymph nodes within 24 hours, and to more distant lymph nodes, bone marrow, spleen and brain within a week of infection. Research by Nicole Baumgarth at University of California – Davis demonstrated premature germinal center collapse, meaning the lymph nodes appeared to be damaged so B cells could not properly mature to produce immunoglobulins.

A group led by Lisa K. Blum at Stanford University in 2018 confirmed again that those who have a stronger immune response are not as sick long-term as those with a weaker immune response. That’s what Raymond Dattwyler said at the June 1994 FDA meeting where the Lyme disease case definition was discussed.

“However, the research by Garg et al. argues that prolonged exposure to tick-transmitted microbes weakens the human immune system increasing the host’s vulnerability to other common microbes’ labelled “non-tick-borne opportunistic microbes,” such as Chlamydia, Mycoplasma, Epstein-Barr virus and many more.”

Anecdotally, many patients are being diagnosed with an immune deficiency condition such as Common Variable Immune Deficiency (CVID) or specific antibody deficiency. Such conditions render a person more susceptible to cancer. The mechanisms below explain how these outcomes occur.

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